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April 21st, 2012
posted by Paul Rega, MD, FACEP April 21, 2012 @ 7:50 am
Antivirals for Treatment of Influenza: A Systematic Review and Meta-analysis of Observational Studies
Jonathan Hsu, Nancy Santesso, Reem Mustafa, Jan Brozek, Yao Long Chen,
Jessica P. Hopkins, Adrienne Cheung, Gayane Hovhannisyan, Liudmila Ivanova,
Signe A. Flottorp, Ingvil Saeterdal, Arthur D. Wong, Jinhui Tian, Timothy
M. Uyeki, Elie A. Akl, Pablo Alonso-Coello, Fiona Smaill, and Holger J.
Schunemann
Ann Intern Med 2012;156 512-524
http://www.annals.org/cgi/content/abstract/156/7/512?etoc
Therapy with oral oseltamivir and inhaled zanamivir may provide a net benefit over no treatment of influenza. However, as with the randomized trials, the confidence in the estimates of the effects for decision making is low to very low.
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